The purpose of this scientific analysis report, CSNF Loading Curve Sensitivity Analysis, is to establish the required minimum burnup as a function of initial enrichment for both pressurized water reactor (PWR) and boiling water reactor (BWR) commercial spent nuclear fuel (CSNF) that would allow permanent disposal of these waste forms in the geologic repository at Yucca Mountain. The relationship between the required minimum burnup and fuel assembly initial enrichment forms a loading curve.